Studies of fatty acid oxidation. 3. The effects of acyl-CoA complexes on fatty acid oxidation*
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چکیده
منابع مشابه
Studies of fatty acid oxidation. 3. The effects of acyl-CoA complexes on fatty acid oxidation.
The oxidation of fatty acids to acetoacetate or to carbon dioxide is affected by the presence of various aliphatic and aromatic acids. For example, benzoate inhibits acetoacetate formation from butyrate at low concentrations in guinea pig liver slices (Jowett & Quastel, 1935b) and in 'cyclophorase' preparations (Grafflin & Green, 1948). Benzoate also inhibits the oxidation of butyrate to C02 in...
متن کاملThe ratio of acetyl-CoA versus free CoA tightly regulates glycolysis and fatty acid oxidation. Malonyl-CoA attenuates fatty acid oxidation by inhibiting acyl-CoA trans- port into the mitochondrion for oxidation and is utilized in fatty acid synthesis
This article is available online at http://www.jlr.org Acyl-CoAs are a class of important molecules that play essential roles in many physiological processes ( 1 ), such as fatty acid oxidation, lipid synthesis/remodeling, ketone body synthesis, xenobiotic metabolism, and signaling pathways. Classically, acyl-CoAs such as free CoA, acetyl-CoA, and malonyl-CoA are recognized as regulators of met...
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In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. S...
متن کاملFatty Acid oxidation defects.
Fatty acid oxidation defects (FAODs) are a group of inborn errors of metabolism that carry a risk for morbidity and mortality. Successful management of these conditions involves early diagnosis, proper management of clinical situations that predisposes to metabolic crisis as well as adequate treatment of a metabolic crisis. The advent of tandem mass spectrometry based newborn screening has redu...
متن کاملFatty acid oxidation
Fatty acids are the preferred oxidative substrates of the heart, skeletal muscles, kidney cortex and liver in adult mammals. They are supplied to these tissues either as nonesterified fatty acids (NEFAI, or as triglycerides after hydrolysis by lipoprotein lipase. During fetal life, tissue capacity to oxidize NEFA is very low, even in species in which the placental transfer of NEFA and carnitine...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1955
ISSN: 0306-3283
DOI: 10.1042/bj0600329